Tuesday, December 3, 2013

MELATONIN TREATMENT IN CHILDREN WITH THERAPY-RESISTANT MONOSYMPTOMATIC NOCTURNAL ENURESIS

To our knowledge, this is the first time exogenous melatonin has been evaluated in the treatment of MNE. Although we observed a change in level and peak-time of melatonin in saliva after the use of melatonin, we did not observe a significant change in enuresis frequency, nor did we observe a change in sleep-wake cycle. Therefore, we conclude that the role of melatonin in the treatment of therapy-resistant MNE is limited. However, the studied population was relatively small and consisted of a select group of patients resistant to all other forms of therapy. Further studies are necessary to explore new treatment options for this difficult group of patients.
http://bedwetting.elsevierresource.com/en/article/S1477-5131(11)00219-1/fulltext

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