Sunday, October 27, 2013

Psammoma bodies


A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word psammos meaning "sand."

Etiology

Psammoma bodies are associated with the papillary (nipple like) histomorphology and are thought to arise from
(1) The infarction and calcification of papillae tips and
(2) Talcification of intralymphatic tumor thrombi. 

Psammoma bodies are commonly seen in certain tumors such as:
·         Papillary thyroid carcinoma
·         Papillary renal cell carcinoma
·         Ovarian papillary serous cystadenocarcinoma
·         Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
·         Meningiomas, in the central nervous system
·         Peritoneal and Pleural Mesothelioma
·         Somatostatinoma (pancreas)
·         Prolactinoma of the pituitary 
·         Mesothelioma, in membranes that line body cavities

Benign lesions
Micrograph of a psammomatous melanoticschwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.


Psammoma bodies may be seen in:
·         Endosalpingiosis
·         Psammomatous melanotic schwannoma
·         Melanocytic nevus

Appearance
Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.

















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