Antimuscarinic agents are the current gold standard for pharmacologic treatment of OAB. Over the past few years, there has been a significant increase in the number of antimuscarinic agents available for treating OAB. All of these agents are effective in improving OAB symptoms, with the maximum benefit derived when combined with behavioral therapy (Burgio et al., 2000). Although similar, differences in these agents may allow one to identify unique agents in select patient populations. Further understanding of the pathophysiology of OAB has prompted the investigation of several pharmacologic agents that target different pathways involved in OAB, which may ultimately provide alternative or combination treatment options.
Posted: 04/07/2010; Urol Nurs. 2010;30(1):29-39. © 2010 Society of Urologic Nurses and Associates