Wednesday, September 26, 2012

Renal Cell Carcinoma - A Reappraisal part 3


RCC occurs in sporadic (nonhereditary) and hereditary forms. Even though hereditary RCCs only consist of 3% to 5% of all RCCs, more syndromes are now being described. These syndromes have proven to be valuable in the development of targeted therapies for the treatment of all types of RCC (Zbar et al., 2007). RCC has been associated with hereditary and non-hereditary risk factors. These risk factors are described in Table 1.
Table 1. Hereditary and Non-Hereditary Rick Factors
Risk Factors
Tuberous sclerosis, von Hippel-Lindau gene, hereditary papillary renal cell carcinoma, hereditary leiomyoma – renal cell carcinoma, Birt-Hogg-Dube syndrome, hereditary renal oncocytoma
Tobacco, obesity, male, African American, hypertension, phenacetin, acquired cystic disease, workplace exposures (such as asbestos, benzene, trichloroethylene)
Source: American Cancer Society, 2011.



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