Thursday, July 12, 2012

Spurious Elevation of Serum PSA After Curative Treatment for Prostate Cancer Clinical Consequences and the Role of Heterophilic Antibodies


In a large cohort of patients, we estimate the prevalence of spuriously elevated PSA values 0.3%. Furthermore, out of 10 patients with spurious PSA elevations prospectively evaluated, none had evidence of interfering heterophilic antibodies. No patient in our series was subjected to unnecessary diagnostic evaluation or treatment. When using PSA for post-prostatectomy surveillance, it is crucial to confirm concerning values and always consider the presence of heterophilic antibodies if the PSA value does not correlate with the clinical scenario.

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