PE is a common condition affecting around one in five men. It can be a cause of significant personal distress which may in turn affect the relationship of the man with his partner. While many men with PE do not seek medical attention, when they do, SSRIs, desensitizing creams and to a lesser extent PDE5-I have been used in the treatment. All of these medications are sold off-label for the treatment of PE except for the recently licensed dapoxetine (Priligy™) which provides an effective, on-demand treatment regimen with relatively minimal side effects. PSD 502 is currently in the development phase and with the conclusion of phase III trials, may soon be licensed as a topical aerosolised spray for the treatment of PE.