Additional research is required to eventually develop a product which is acceptable to the patient by being effective all of the time with minimal side effects and that is easy and discreet to use without compromising spontaneity during sexual intercourse. Some of the possibilities are as follows:
- 9-hydroxycanthin-6-one (9-HC-6-one), a β-carboline alkaloid isolated from Eurycomalongifolia. In vitro, it has been noted that 9-HC-6-one attenuated PE-induced contraction by blocking calcium channels [Chiou and Wu, 2011].
- It has been noted that decreased levels of magnesium may give rise to vasoconstriction from an increased thromboxane level, increased endothelial intracellular Ca2+, and decreased nitric oxide. This mechanism has been attributed to PE [Mohammadreza et al. 2009].
However, there is a long way to go before these products can be marketed. Moreover, reproducible in vitro and in vivo studies are required and the formulation of a standardized definition of PE is possibly the first building block towards standardization of PE research.