Wednesday, May 23, 2012

GFR measurement

GFR measurement requires quantification of creatinine from timed urine collection or can be estimated by the Schwartz formula. Timed urine collection from children can be unreliable and inaccurate, especially in incontinent children. Factors that affect GFR include age, gender, and body size. GFR matures over the first 2 years of life after correction for 1.73 m2 body surface area. GFR may be reliably calculated by the Schwartz equation:

GFR (mL/min/1.73 m2) = 0.413 X height (cm)/serum Cr (mg/dL) (Schwartz et al, 2009).

Classification of Chronic Kidney Disease for Children Older than Age 2 Years
STAGE                                                    DEFINITION                                            GFR (mL/min/1.73 m2)
1                                                    Normal or GFR (with kidney damage)                     90
2                                                    MildGFR (with kidney damage)                               60-89
3                                                    Moderate GFR                                                           30-59
4                                                    SevereGFR                                                                15-29
5                                              Kidney failure                                                       <15 or dialysis



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