Tuesday, April 24, 2012

Up-regulation of Plakophilin-2 and Downregulation of Plakophilin-3 are Correlated With Invasiveness in Bladder Cancer


We conclude that Pkp2 mRNA and protein expression levels are elevated in invasive bladder cancer cell lines, whereas Pkp3 mRNA and protein expression levels are decreased in invasive bladder cancer cell lines, relative to noninvasive cells. Moreover, Pkp2 and 3 do not appear to be recruited to the plasma membrane but persist undegraded in the cytoplasm of invasive bladder cancer cell lines and tissues. Based on these data, as well as knockdown experiments, Pkp2 and 3 are likely to be involved in invasiveness through the mediation of loose cell adhesion but are probably not involved in the modulation of cellular growth.
UROLOGY 79: 240.e1–240.e8, 2012. © 2012 Elsevier Inc.

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