Our data underline the individuality and poor prognosis of squamous cell cancerous lesions of the urinary tract. If local surgical control is achievable, radical surgery remains the treatment of first choice with a possible, curative potential. In our collective, the application of adjuvant chemotherapy and radio-chemotherapy was successful in selected patients. The histogenesis of pure SCC lesions and their connection of TCC with squamous differentiation are not conclusively defined. Further studies are needed in fundamental, histopathological and molecular research while clinicians should undertake combined efforts to merge and analyze clinical data in order to optimize the treatment of patients with rare urological tumor entities.