Since salvage RP is limited in clinical practice due to much higher morbidity than primary RP , salvage whole gland cryoablation has emerged as an option with acceptable long-term oncological outcomes and lower side effects. However, significant side effects are possible, including urinary retention (3.0–8.5%), incontinence (4.4–13.0%), rectourethral fistula (0–3.3%), and erectile dysfunction (61.5–100%) [7,8,9].
In order to decrease complications of salvage cryoablation, several investigators have tried to apply salvage focal cryoablation to small numbers of patients with biopsy-proven unilateral recurrent PCa after radiotherapy. Salvage focal cryoablation of the prostate for locally recurrent PCa after radiotherapy failure was first reported by Eisenberg and Shinohara in 2008 . Several recent publica- tions also showed encouraging outcomes of salvage focal cryoablation for locally recurrent PCa after radiotherapy failure. However, all these studies had small patients’ numbers (the biggest number is 44 patients) [9,11,12].
In this study, we report the outcomes of salvage focal cryoablation at a large number of academic and community centers that have participated in the COLD Registry. To our knowledge, this is the largest data set assembled for salvage focal cryoablation for the treatment of localized PCa recurrence after radio- therapy.